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The discrepancy in the nature of this association, mainly in relation to the first two hypotheses Tobacco smoking as a potential risk factor to first-episode psychosis and Nicotine use in the form of tobacco smoking in first-episode psychosis: the self-medication hypothesis makes it difficult to clearly understand which hypothesis contributes more to the aforementioned relationship, although, according to this review, there is a trend toward a greater contribution by the first proposed hypothesis

In IBD, smoking has been shown to exert opposite effects on UC and CD

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